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How it works?
The arteries that feed the spongy tissue in the penis dilate when they receive signals from the brain. The signal is carried by nitric oxide in the blood. It switches on the enzyme which makes a molecule known as cGMP (cyclic Guanosine Monophosphate). This triggers smooth muscle in the artery wall to relax and so the blood vessel dilates . However, the cGMP is broken down by another enzyme known as PDE (Phosphodiesterase) causing the arteries to narrow again - bringing an end to the erection. Kamagra™ inhibits the PDE and stops it from breaking down the cGMP. In this way, the natural erection is maintained. It doesn't last forever - only as long as the natural stimulation remains.

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What if I miss a dose?

This does not apply.

What drug(s) may interact with Kamagra?

Do not take sildenafil if you are taking the following medications:

• nitroglycerin-type drugs for the heart or chest pain such as amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin, even if these are only taken occasionally

Sildenafil may also interact with the following medications:

.alpha blockers, used for high blood pressure or an enlarged prostate. NOTE: Do not take doses of sildenafil higher than 25 mg within 4 hours of taking alpha blockers, such as alfuzosin (UroXatral®), doxazosin (Cardura®), prazosin (Minipress®), or terazosin (Hytrin®).

• bosentan
• certain drugs used for seizures such as carbamazepine, phenytoin, and phenobarbital
• certain drugs used for fungal or yeast infections, such as fluconazole, ketoconazole, and voriconazole
• certain drugs for the treatment of HIV infection or AIDS
• cimetidine
• cisapride
• clarithromycin
• diltiazem
• erythromycin
• grapefruit juice
• mibefradil
• monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar.)
• nitroprusside
• rifabutin
• rifampin
• quinidine
• some drugs for treating depression, anxiety or other mood problems (examples: fluoxetine, fluvoxamine, nefazodone)
• verapamil

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

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